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Analizator tlenku azotu - NOA280i

Nitric Oxide Analysis

GE Analytical Instruments manufactures the Sievers Nitric Oxide Analyzer (NOA) for nitric oxide research and analysis. In biological systems, nitric oxide is produced from the enzymatic oxidation of arginine. Three isoforms of the enzyme nitric oxide synthase (NOS) have been identified in many cell types: endothelial NOS, neuronal NOS, and inducible NOS. The biological functions of NO include action as a vasodilator, neurotransmitter, cytotoxic agent, inhibit of platelet aggregation, and activator of smooth muscle proliferation.

Nitric oxide is also present in exhaled breath and may be a useful marker of airway inflammation.

In solution, nitric oxide reacts with molecular oxygen to form nitrite (NO2-), and with oxyhemoglobin and superoxide anion (O2-) to form nitrate (NO3-). NO also reacts with thiols to form S-nitroso compounds, amines to form nitrosamines, and metals to form metal nitrosylcomplexes.

The Sievers Nitric Oxide Analyzer (NOA 280i) offers the most versatile detection system for Nitric Oxide (NO) analysis. Employing GE Analytical Instruments' highly sensitive, ozone-chemiluminescence technology, the NOA 280i has unsurpassed versatility for liquid and exhaled breath NO measurement. With over 600 publications using the Sievers Nitric Oxide Analyzer, the NOA has proven to be the instrumentation of choice by researchers worldwide.

Overview

The Sievers Nitric Oxide Analyzer (NOA 280i) offers the most versatile detection system for Nitric Oxide (NO) analysis. Using GE Analytical Instruments' highly sensitive, ozone-chemiluminescence technology, the NOA 280i has unsurpassed versatility for liquid and exhaled breath nitric oxide (NO) measurement. With over 700 publications using the Sievers Nitric Oxide Analyzer, the NOA 280i has proven to be the instrumentation of choice by researchers worldwide. The Sievers NOA can be used to measure liquid samples or exhaled breath samples of nitric oxide.

Liquid Samples

The NOA 280i measures nitric oxide, nitrite, nitrate or nitrosothiols in most biological samples. Concentrations, ranging from low nanomolar to millimolar levels, can be measured in sample volumes ranging from a few microliters to several milliliters.

Exhaled Breath Samples

Exhaled nitric oxide can easily be measured with the NOA 280i. Fast response time and low sample flow rates allow for measurement of exhaled NO in humans and animals.

PURGE SYSTEM

Custom Purge System with Condenser and Heating Jacket. Includes purge vessel, filter line with IFD filter, NaOH trap, Teflon tubing and fittings. For analysis of nitric oxide, nitrite, nitrate and nitrosothiols in biological samples such as plasma, cell culture media, or tissue czytaj więcej

LARGE VOLUME PURGE SYSTEM

Designed for measurement of larger volume samples (> 100 μL), the Large Volume Purge System has about twice the volume of the original purge system and permits measurements of nanomolar levels of NO and its reaction products without the need to frequently change the reagent. Current users czytaj więcej

LIQUID SUPPLIES KIT

This kit includes all of the amlessories for liquid measurements including ring stand, clamps, syringes, pipettes, filter paper, and sample tubes and rack. Part Number: ASK 14300 czytaj więcej

NITRITE CHEMICALS KIT

All the chemicals for nitrite measurement including sodium iodide, acetic acid, and sodium nitrite. Part Number: CASK 14500 czytaj więcej

NITRATE CHEMICALS KIT

All of the chemicals for nitrate measurement including VCl3, 1M HCl, 1N NaOH, and sodium nitrate. Part Number: CASK 14400 czytaj więcej

GAS SAMPLING INTERFACE

For gas-phase calibration of the NOA and measurement of gas-phase samples. The kit includes a Nafion drier, 0.45 µm particle filter, Teflon sampling line with luer adapters, luer plug, and a calibration tee. Part Number: CASM 03300-02 czytaj więcej

ENO CALIBRATION GAS

Calibration of the NOA for gas-phase measurements is easily performed using this lightweight, disposable cylinder of 45 ppm NO in N2. Part Number: CNDK 01400 czytaj więcej

ZERO AIR FILTER

Calibration of the NOA for gas measurement also requires a gas contains low levels (< 1 ppb) of NO. This is easily produced from room air using a cartridge containing KMnO4 and activated carbon. The trap has sufficient capacity for several years of use. Part Number: CACT 01400 czytaj więcej

CALIBRATION KIT

Includes the Zero Air Filter, ENO Calibration gas cylinder, a low flow regulator preset to 300 mL/min gas and a calibration tee. Part Number: CNCK 01400 czytaj więcej

PURGER SEPTA

One set included with Purge System. Part Number: CHMI 00140 czytaj więcej