GE Analytical Instruments manufactures the Sievers Nitric Oxide Analyzer (NOA) for nitric oxide research and analysis. In biological systems, nitric oxide is produced from the enzymatic oxidation of arginine. Three isoforms of the enzyme nitric oxide synthase (NOS) have been identified in many cell types: endothelial NOS, neuronal NOS, and inducible NOS. The biological functions of NO include action as a vasodilator, neurotransmitter, cytotoxic agent, inhibit of platelet aggregation, and activator of smooth muscle proliferation.

Nitric oxide is also present in exhaled breath and may be a useful marker of airway inflammation.

In solution, nitric oxide reacts with molecular oxygen to form nitrite (NO2-), and with oxyhemoglobin and superoxide anion (O2-) to form nitrate (NO3-). NO also reacts with thiols to form S-nitroso compounds, amines to form nitrosamines, and metals to form metal nitrosylcomplexes.

The Sievers Nitric Oxide Analyzer (NOA 280i) offers the most versatile detection system for Nitric Oxide (NO) analysis. Employing GE Analytical Instruments' highly sensitive, ozone-chemiluminescence technology, the NOA 280i has unsurpassed versatility for liquid and exhaled breath NO measurement. With over 600 publications using the Sievers Nitric Oxide Analyzer, the NOA has proven to be the instrumentation of choice by researchers worldwide.

Overview

The Sievers Nitric Oxide Analyzer (NOA 280i) offers the most versatile detection system for Nitric Oxide (NO) analysis. Using GE Analytical Instruments' highly sensitive, ozone-chemiluminescence technology, the NOA 280i has unsurpassed versatility for liquid and exhaled breath nitric oxide (NO) measurement. With over 700 publications using the Sievers Nitric Oxide Analyzer, the NOA 280i has proven to be the instrumentation of choice by researchers worldwide. The Sievers NOA can be used to measure liquid samples or exhaled breath samples of nitric oxide.

Liquid Samples

The NOA 280i measures nitric oxide, nitrite, nitrate or nitrosothiols in most biological samples. Concentrations, ranging from low nanomolar to millimolar levels, can be measured in sample volumes ranging from a few microliters to several milliliters.

Exhaled Breath Samples

Exhaled nitric oxide can easily be measured with the NOA 280i. Fast response time and low sample flow rates allow for measurement of exhaled NO in humans and animals.